Researchers have successfully utilized the power of artificial intelligence (AI) to discover groundbreaking senolytic compounds that can combat age-related processes such as inflammation and cancer. Using deep neural networks trained on extensive experimental data, scientists identified three potent drug candidates from a pool of over 800,000 molecules, offering promising clinical properties that surpass existing senolytics.
In a recent publication in Nature Aging, Integrated Biosciences, a biotech company amalgamating synthetic biology and machine learning to tackle aging, showcased the utilization of AI in identifying new senolytic compounds. Senolytics, small molecules that have attracted attention for their potential to hinder age-related ailments like fibrosis, inflammation, and cancer, were the focus of this collaborative effort between Massachusetts Institute of Technology (MIT) and the Broad Institute of MIT and Harvard.
Senolytics selectively induce programmed cell death in senescent cells, which are associated with aging and various age-related diseases. Despite promising results, most identified senolytic compounds have encountered challenges such as poor bioavailability and adverse side effects. Integrated Biosciences, established in 2022, aims to overcome these obstacles, target neglected aging hallmarks, and advance anti-aging drug development using AI, synthetic biology, and other advanced tools.
The researchers employed deep neural networks to predict senolytic activity, leading to the discovery of three highly selective and potent senolytic compounds from a vast chemical space. These compounds displayed favourable chemical properties and demonstrated efficacy in clearing senescent cells and reducing the expression of senescence-associated genes in animal studies.
This groundbreaking work paves the way for therapies that address aging and holds significant promise for longevity research. Integrated Biosciences' innovative platform combines systems and synthetic biology, propelling drug discovery and pushing forward advances in anti-aging medicine.
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